Apocalypse and Sinister run off different scales - Sinister is about manipulating genetic code, whether his own or others to produce ultimate mutants e.g., Cable. Apocalypse is about grand conquest and total planetary domination. While the methods of Sinister may seem harsh they are relatively contained. Apocalypse not so much.
The missing component for a competent definition of sociopathy is the attempt to 'appear normal' - something Sinister doesn't even begin to try to do outside of a larger plotline, but still, that's not the norm.
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