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Posted by Illyana Rasputin

Yes, it can,

Posted by jordama
@Illyana Rasputin:

are they cured or just die?
Posted by 244
@jordama: Some of the New Mutants characters were corrupted by black magic from Chris Claremont's Demon Bear saga and Illyana had cleansed them with her soulsword leaving them whole, as for vampires, if they're mere mystical creatures who weren't formerly human, I think the weapon would kill them.