Seem's like every comic Deadpool's in he's acknowledge that there is a world outside the comic and that he's even in one. This picture is from Cable & Deadpool 49, but almost all of Deadpools: Wade Wilsons War is him in the Past narating what is going to happen in the future when he goes on trail for the fiasco in Mexico.
I love it, some people hate it though... they say that it takes them out of the comic since Deadpool is reminding you your reading a story not living in the fantasy world. I personally think it's hillarious. Makes me laugh every time. It's just part of Wade's charm as a human being. Just like his inner voices, softer side, and his funny, sometimes deranged banter.