A lot of the big team is just cannon fodder here, they really don't need to be on the team. But I'd guess that the big team could eventually take the hairy guys down. Not easy though.
Here's what they'd probably do. Cyke, Banshee, Shocker, and Gambit would attack from a distance. Between them, they'd do a decent amount of damage and at least temporarily stun them.
Then Lizard, Rhino, Luke Cage, Iron Fist, Sabretooth, Doc Ock, Beast, and Cyber come in for the close-up attack. Individually they'd get knocked down pretty hard, but together they could potentially do some more damage, especially Rhino, Cage, Iron Fist, and Cyber (with his poison). Then they might step back and let the distance team blast 'em again from close up.
But they'd lose a number of guys before they eventually won.