I feel like the spin off would have to be a character introduced that isn't a regular, so that (in my mind) rules out people like Skye and FitzSimmons.
And Ward being who he is, I don't think he could carry his own show. Man needs some context otherwise he's kinda pointless. He's kinda psychopath.
I could see maybe Bobbi or Mack spinning out to something else, maybe with Hunter. Or the Inhumans, but without Skye. But an Inhumans show so soon, with the movie like 3 or 4 years away, seems weird to me. They would have a ton of ground to fill leading to the movie, which is why introducing Inhumans this season seemed so odd to me, even before the Inhumans movie was delayed due to Spider-Man.
Assuming I know i only have a year, I would use my powers to benefit myself in the long run as much as possible (steal some money, obtain some material goods the easy way, read books to get smarter etc) and then once that's squared away I'll help people as much as I can to make up for all the bad karma I've accumulated.