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Rose Canton was a Golden Age Flash villain with a split personality. Her good side (Rose) was a mild-mannered botanist, but her evil side (Thorn) was a psychotic criminal with the power to control plants. Rose eventually committed suicide to prevent her Thorn personality from doing further evil.
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Shockwave is the Decepticons' military operations commander
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Doomsday was built to survive at all costs. Created millenia ago, his cruel and inhumane upbringing and long history of battle have made him a ruthless monster. He is most famous for being responsible for the Death of Superman.
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Annihilus, a native of the planet Arthos, is the ruler of The Negative Zone and a longtime foe of The Fantastic Four. He is a nihilist who is obsessed with constantly finding different ways to extend his lifespan and destroying all that which he sees as a threat to his existence.