I've been considering this in terms of how irradiated characters - and some major Omega mutants - tend to have mutant offspring more than the general populace, and how those children tend to exhibit mutant powers younger.
(Keep in mind I haven't taken a science class since the 90s... )
To assume normal science applies, suppose the X-gene is a highly rare and recessive trait. So, clearly two mutant parents are likely to have mutant children - since both have the recessive gene. But, let's assume that many other genes/traits act as co-factors, so just having the gene isn't the ultimate guarantee of exhibiting powers. Maybe then stronger mutants would have a higher chance of having mutant offspring - as, theoretically, they don't have any other traits that could interfere with the function of the mutated gene.
For the irradiated characters, I assume that the radiation somehow turns their gene to "on" for reproductive purposes. Maybe it irradiates the dominant gene into irrelevance? It doesn't necessarily make them mutants, but it nearly guarantees their offspring will have mutations - and maybe realize them at a younger age.
Clearly there's no single answer, as comics weren't always so invested in the inner workings of their characters. But, as for fanwankery, this works for me.
Still not sure how to explain Nightcrawler/Madrox mutants.
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