Off My Mind: How Do You Define A Hero's Arch Enemy?

Arch Enemies every hero should have one, Batman has The Joker, Superman has Lex Luthor, The Doctor has The Master and Wolverine has Sabretooth, but for some heroes it's hard to define just who their arch enemy is: 
Take Spider-Man for as a prime example right now he has four maybe five portial arch enemies: Norman Osborn, Venom (symbiote), The Kravinoff Family, Doc Ock and the Sinister Six. The Sinister Six don't appear often enough to really be his ARCH enemies, Doc Ock whilst a strong contend for the award of the web heads worst enemy the remaining three deserves it more. 
Norman Osborn has screwed up Spidey's life countless times, from getting Gwen Stacy pregnant then killing her after she'd given the twins away (but he didn't kill her for giving them away , in fact I don't think he knew about them until they showed up years later), to causing the Clone Saga 'from beyond the grave'
Most recantly Dirty Norman got his son's girlfri end pregnant and forced him to join his Dark Avengers before Spidey stepped in and saved the day. 
So Norman is certaintly deserving of Arch Enemy status but then so is Venom, the symbiote that tried to take over Spidey's mind and body then attached itself to someone how hated Spidey just as much as it did Enter: Eddie Brock sharing some of Spidey's powers aswell as a few of his own Venom (recantly bounded to Mac Gargan formally known as Scorpion) is a worthy foe to everyones favourite Web-Slinger, but in recent years its been the Kravinoff family who have caused Spidey the most pain putting him though a g auntlet  of his old enemies in order to prepare him for the Grim Hunt so as it stands right know the Kravinoff family are Spidey's arch-enemies but over all Venom and Norman are really the only contenders for the title. 
Who would you say Spidey's biggest foe is and why?
How do YOU define a heroes worst enemy, do judge it by who they've fought the most, or by how the characters are two sides of the same coin (like Spidey and Venom or The Doctor and The Master) or even by how badily the villain has screwed up the heroes life? 
Please do let me know
Your faithfully
Kingfrogger666
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