@jackofspades: Juggs is a PRIME example of someone hampered by not being able to fly. If Juggs could fly he could beat Superman, Firelord or Wonderman. Because he can't fly he can be BFR'd which is a loss on battle forums. also because he can't fly he can only stalemate those opponents. Whereas if he could fly, he could beat them.
iam not going to put all the reasons why juggs is a beast without flight you can look here\ http://www.comicvine.com/juggernaut/4005-1445/forums/juggernaut-respect-thread-22109/AND HERE \http://www.killermovies.com/forums/showthread.php?postid=10048750
Professor X didn't really use his powers for offensive attacks at all in the films, I don't see how he solos. Maybe he makes Superman see illusions or make everyone invisible but that's it really.
If his showings are canon in X-Men: First Class - where he's freezing the minds of buildings full of people I don't see how he doesn't do the same to MOS. Although I think he might have put Jean Grey into a coma in the third film - don't quote me on that though.
I haven't played Prototype but if whatever heconsumes he gets the powers and abilities of then speed is not an issue. he would have Flash and Zoom's power. he would have collective surability of many characters. if that is how Mercer's powers work then Superman gets completly stomped.