@CitizenBane: No, Death said if they tried to bind him again he'd kill them. Asking for his help isn't off the table. And if Death sees Genesis as a threat then...there ya go. According to the wiki, Jesse (w/Genesis) doesn't have any other superhuman attributes other than the Word. He's not invulnerable. I don't see why the Colt wouldn't take him out. Or just a regular gun for that matter. The Winchesters have A TON of tricks up their sleeve. It's hard to see how they wouldn't pull out of this. On a side note..I wonder if Supernatural Death can refuse to reap someone a la Marvel Death. Wonder if he could just give Sam and Dean temporary immortality to win this fight?