@god_spawn: I'd disagree since Deadpool has better healing and no adamantium but has been aced by Hulk and other high powered characters. Hell he's been splattered by cars. He's just able to pull himself back together.
But Deadpool also has his fair share of tanking powerhouse showings like tanking hits from Colossus, She-Hulk, Hercules, Moonstone, etc. Daken has tanked blasts from Cyclops and Thor, hits from an enraged Thing and Skaar. He has been within buildings exploding with little to no effect. Laura has been in the heart of explosions that took out large buildings only to come out incredibly burnt but conscious. Even Logan without his adamantium was tanking hits from Mr. Hyde and the Hulk. If it were just the adamantium then his kids shouldn't have inherited his damage soak. I know it doesn't really make sense when it's just super fast healing and the adamantium is a more legitimate option, but it isn't always the case in the comics. It's consistent enough and spread throughout quite a few characters.