Brubaker know's how to write an integrating female leading character. He did it on his run with Catwoman and then again with Fatale. I'm guessing he'll do it again with this. Plus this has some banging art. On my pull list!
I'm going to go with Image on this one just for the fact most of there comic actually star a female character rather then having them as secondary characters, less then the male character, or just as a throw in character.