Midnighter is a joke next to most Spider-Man enemies. it's not trolling, he's terribly over-rated on the vine and without PIS he has no chance. He's only a bit above street levelers like Cap and Batman but got an inflated rep here cos Buckshot used to fanwank him a few years back. Midnighter has been manhandled by speedsters before, he can be fast but he's just not fast enough. Although you may know the combination of blows going to be thrown, you still need to avoid them.
Spiderman and the like of friends like Goblin and Venom have too great a reaction speed and strength advantage to overcome in this context when you combine it with the slight offensive/defensive offset granted by his spider sense and Spidey got a healing factor. Although only intuitive and not all seeing, it does allow some offset against the simulator.
Spider-Man enemies are typically much faster than him, without doors Midnighter is as good as dead.
He's got great damage soak but he is not durable and he is not strong (rated at 1-2 tonnes)
Spider-Man enemies could typically rip off his head with one punch