This is a bunch of Batmen and Jedi vs eight two-ton nigh-invulnerable bullet-timing ninjas. The Spartans might damn well speedblitz, Cortana can effectively take control of the Citadel very quickly, and the Arbiter is invisible. The biotics are powerful, yes, and it's a fight if it's at a distance, but they're not going to stop all the Spartans before they can close the gap. They can also straight tank the Mass Effect weapons if they just charge them (they'll need longer than a Spartan's sprinting to take down their shields and get through their armor), and with the way the Spartans fight, even one or two can manhandle the Mass Effect crew in CQC.
And that's just an open fight between the Spartans and the ME crew. Add in the fact that the Halo team are incredibly stealthy (the Halo games are pretty severe "one-man-army" exceptions, in most of the EU material the Spartans never even get seen, especially the S-III's), plus can take over Citadel systems with Cortana, and can bring straight up heavier firepower, I think the ME guys are just outmatched.
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