Black Panther has Achebe and Killmonger. Possibly White Wolf too, though if they go that route it will just be retreading Thor/Loki territory. Man-Ape is terrible. Strange should be fine, he has plenty of villains to choose from. Umar could be a good villain as well, and it'd be interesting to see if they do Shuma-Gorath. Ant-Man has no villains except Ultron, and Scott Lang doesn't even have that.
Carol's villains are useless, though. The only decent villain she ever had was Mystique, and Marvel can't use her. And the Inhumans have a grand total of one villain, Maximus.
One thing is that Thor has pretty much assembled every single female Avenger with a few extra's, which is pretty nifty.
But how exactly is it the Destroyer shrugs off the axe, when the axe actually worked as intended against Celestials and the Destroyer was (putting it bluntly) a miserable failure. I suppose I am just over thinking it...
The Axe was enchanted specifically to cut through Celestial Armour. That doesn't mean it can cut through anything.