Nah, Spider-Man has no real advantage on Iron Man other than agility. Even then, Iron Man's targeting system was pretty insane. He also won't be dodging a full on tackle from IM if were to go super-sonic (which he does rather easily). Spidey can't hurt him (took a tank shell pretty well, and automatic fire, a serious beating from Iron Monger at low power).
But still Tony didn't showed a lot of speed or strength in the movies, I remember him having problems picking up a car in Iron Man 1. But he was able to fight Thor in Avengers movies, maybe Iron Man's biggest advantage here are his weapons and his durability, Spider-man in the movies stopped a train and suvived to multiple kinds of bombs, also Sandman punishment in Spider-man 3.
I need to think this better.