Mary Jane made the deal with Mephisto to fix Peter's life. So all blame is basically on her, though nobody knows that. What they remember is that Spider-Man and Mary Jane did not get married because she only wanted to marry him to have children. She then said that she wouldn't put a child in their lifestyle, so she would stay with him but she won't marry him. So basically, every event has happened exactly the same up to Civil War except that they weren't married. They were still together the whole time though. During Civil War, everything happens the same up to May getting shot. After she gets shot, Peter manages to revive her at the hospital. Kingpin hires a hitman to take out Mary Jane and her family as revenge for Spider-Man beating him up in prison. Spidey saves her, but she is injured badly. He takes her to Dr. Strange who heals her and Spidey begs Dr. Strange for help. He asks him to cast a spell so everyone will forget that he is Spider-Man. He told him that he can't do it alone and that he'll be back. He enters a astral projection and goes to talk with Mr. Fantastic and Iron Man.