Who cares if a Deadpool movie flops if it's R-rated if the movie is the best quality possible? Who cares about sequels if the price is watered down products?
Studios only care about profit, we the audience should care about quality.
Hitchcock's Vertigo was a flop and it's considered to be a movie masterpiece nowadays. Deadpool isn't going to be a Hitchcock film but nothing should stop it's potential to be the best possible movie it can be.