So I wonder if that's just a reference or foreshadowing for Vulture and Ock
I believe it does. I think they are working pretty quickly on trying to form the Sinister Six. Just by the trailer alone it they are introducing Electro, Rhino and I think I saw the Green Goblin. The Lizard was in the first movie and they are foreshadowing Vulture and Doc Ock for the future. That makes enough to form the Sinister Six. Spider-Man had a hard time with the Lizard and I cannot wait to see how he stepped up his game in the next movie. If/When he fight the Sinister Six I wonder if he is going to do it solo or is going to recruit some superhero help from the marvel universe.