Wolverine's always been one of my favourite characters but over the years he's become a bit of a joke, constantly getting his arse whooped, filling in his back story and ruining the mystery. Its a shame but they've completely ruined him. The last person that gave him a decent storyline was Mark Miller. *sulk*
I think Mark Miller's run on Wolverine would make a brilliant adaptation as it reads like a film anyway.
Secret invasion would be brilliant as well because of the vast amount of characters involved it would be nigh on impossible to make as a film, and if it was successful it could lead to loads of other spin off's like the dark avengers and possibly even siege, although i know that's not many people's favorite I did enjoy it.
Civil War would be an option as well due to the amount of characters and the fact that its unlikely to be made into a live action movie.