"This is a Question for anyone who has read Deadpool for a while, and has read both of the current series's: For someone who just wants to jumps into a Deadpool book, who just wants some good laughs and is just looking for a good story (which I don't mind 6 issue story arcs), which series is worth picking up out of the the two (Deadpool or Deadpool: Merc with a Mouth)? "
Out of those two, I would definitely read Daniel Way's Deadpool. I really like his writing, especially with Deadpool, because he can mix the right amount of humor, action, plot twists, and insight into Wade's personality. Merc with a Mouth, from the first two issues I read, is just stupid jokes Deadpool spews out rather than laughs arising from the crazy situations Way puts him in. New readers, however, might want to check out Deadpool Team-Up #899 (which I think comes out this week?). I think it'll mostly be self-contained stories, so you won't need to know much continuity-wise. If you like what you read, then maybe you'll want to plug into the other series.