Pyg was created by writer Grant Morrison .
The name Professor Pyg was inspired by two Rex Harrison characters, Doctor Dolittle and Henry Higgins in My Fair Lady (a musical adaptation of the play Pygmalion by George Bernard Shaw, which was itself based around the myth of Pygmalion).
Pyg's first chronological appearance was in Batman #666, in a grim future where Damian Wayne was Batman and Gotham City was on the verge of the apocalypse. Pyg was a member of Damian's rogues gallery, until he was crucified upside-down on a cross by the Anti-Christ Batman.
In present day Batman continuity, Pyg faces Dick Grayson and Damian Wayne in the first story arc of Batman and Robin soon after Bruce Wayne's ostensible demise. Pyg's diabolical plans are thwarted and he is apprehended.
In Batman and Robin #13, Professor Pyg is broken out of prison by the minions of El Penitente during his return to Gotham City. An army of Pyg's dollotrons attack an incapacitated Commissioner Gordon and Dick Grayson, while he is presented with a new pig mask courtesy of El Penitente. Pyg works with Doctor Hurt to tear down the Wayne family name and destroy Gotham. Pyg captures James Gordon and attempts to turn him into a dollotron, but Robin foils his plans and saves Gordon. Batman soon comes in and turns Pyg's dollotrons against him, and then brings Pyg to justice.
Lazlo Valentin was once an agent of Spyral, who designed neo-pharmaceutical products such as the mind eroding gas compound which the crazed Dr Dedalus uses in his final confrontation with Batman (during the events of Leviathan Strikes!). Whilst working for Spyral, Lazlo was also subjected to the compound whilst in the Labyrinth for which "the only exit was via violent paranoid schizophrenia, drug abuse and D.I.Y surgery...Lazlo became Professor Pyg."
In current times Pyg is an insane scientist who turns people into "Dollotrons", things that resemble red-haired Kewpie dolls. They are his idea of "perfection". He creates them by attaching masks to their faces, masks that seal themselves onto the victim and start to transform their head. He then surgically alters them himself. They have no will of their own, only silently following Pyg's orders as he plans to turn "everyone perfect".
Major Story Arcs
A Court of Owls
For more information see : A Court of Owls
While Batman investigates Dan Matthews, a guard at Arkham Asylum who maybe on the take, Dan in a desperate attempt to get away, opens several of the inmates cells. Pyg is one of those inmates seen attacking the Batman before the Joker appears to come to Batman's aide and the pair work together to beat back the group of rampaging inmates.
Seeds and Dirt
Backup story in: Detective Comics #14
Pyg is seen on a monitor in Arkham Asylum.
Brave and the Bold
During "Knights of Tomorrow!" Robin is shown punching both Pyg and Flamingo. Both of these villains were introduced/prominant in to the Batman and Robin comics.
Beware the Batman
Professor Pyg will apear as a major antagonist in the animated series Beware the Batman.