For me, the funniest comic moment was in the most recent Deadpool comic (#4 I think...). The entire dialogue with the hunchback was awesome, especially with the reference to "Young Frankenstein".

"It's pronounced 'Eye-gore'." Hahaha.

Now that I think of it, most of that book was great. The exploding chair was kinda funny too.

"This chair's pretty comfy."
"Yea, but can it explode?"
"......"
"That's what I thought."