Tigra has quest appeared in many comics over the years, and as a long lasting member of West Coast Avengers. One could think that she doesn't have enemies of her own, but she too has brought some villains to Marvel Universe.
 
Malcolm Donalbain
Malcolm was her first villain, who she fought as still human. She had slightly above normal feats thanks to Malcolm's funding. Malcolm died when they fought, not by her hands, but by his own.
 

Zabo
Zabo is Malcolm's brother; she first met him along with his brother. Zabo escaped the first confrontation, but he blamed Tigra for his brother's death. Only after she was tuned into furry heroine, he was able to find her. Spider-Man even helped Tigra to fight Zabo, but she was able to convince him to make peace with the past.
 

Surisha
Surisha was a demoness living in sewers, thought she had a beauty of a princess; she needed human life-force to keep it. His minion helped her and she helped him back. Tigra tracked them under the city and used her minion to end Surisha.
 
 

Aesklos
Aesklos was said demoness' minion; he had symbiotic relation with her. He hunted for humans and drained their life-force; he then returned to their underground lair and feed Surisha. That in turn kept him alive and gave him purpose. Tigra managed to convince Aesklos to feed on Surisha, and that killed them both.

 
 
Cougar
Cougar was one of  the Cat People that had evolved on earth, separated from their brothers in Land Within. He had selfish wishes and they involved power. He managed to get his hands on Null-Bands and tried to use them to siphon Thing of the Fantastic Four power. Tigra fought against his plans, and he too was killed, though yet again not by Tigra's hands, but by his own human lover.
 

Tabur
Tabur is creation of High Evolutionary from a regular house cat. He was left alone to earth back when High Evolutionary flew to space to inhabit his own planet. He was bitter and angry. Cat People took him in and helped him. He in-turn tried to help them by wanting to conquer the earth for them. Earth-bound Cat People, who that day revealed themselves to humans, and Tigra fought against him. In the end he was turned back to house cat.
Tigra had second confrontation with him years later, when Tabur had claimed the crown of Cat People living in Land Within.


Sultan
Tigra found a new enemy in Australia when she lived with aborigines in the jungle. He had hired a band of mercenaries to kidnap local people and then he sold them. Women however were brought to his personal harem. Tigra too was captured, and used her sexiness to get close to him. Tigra's friends were released and returned to their homeland. Sultan was left behind swearing revenge.

    

Brethren of the Blue Fist
Brethren of the Blue Fist was a group of police men who fought crime by killing criminals. Ironically the group was founded by Tigra's dead husband. In fact he was killed by the same group when he thought they have gone too far. Tigra used false alias to draft into police academy, and let herself initiated to the Blue Fist. Then from the inside she brought them all to justice, and completed police training to boot.

2010 promises to be full of Top Cow comics. we have confirmation of Magdalena ongoing, Cyberforce ongoing, Angelus mini, Randy Queen's Starfall and Artifacts series. Plus we have a new Pilot Season coming also in 2010 with all original concepts
 
Links for the news: 
 
Magdalena & Angelus
Cyberforce
Artifacts

We got news of Top Cow's next summer event called "Artifacts" it about those 13 Artifacts and what would happen if they ever got together.

Top Cow announced today at San Diego Comic-Con that Ron Marz is writing the company's next big summer event for 2010: Artifacts.

"The 13 artifacts in the Top Cow universe tend to be the connective thread between a lot of the characters and the concepts. So this will bring virtually everything that's happening in the universe together by bringing these 13 artifacts together," Marz said of the 13-issue series. "The intention is to do this in a way that is, with the risk of sounding cliche, going to be the biggest, universe-changing story, in terms of permanent change. I don't know if we can tell a bigger story than this."

As fans of Top Cow know, "artifacts" are objects of power that are important to the publisher's supernatural world, particularly in the comics The Darkness and Witchblade.

"The Darkness and the Witchblade and the Angelus Force are collectively known as the trinity and are supposed to be the most important among all the artifacts," Marz explained. "The Darkness is the dark side, the Angelus is the light side, and the Witchblade is supposed to be the balance between the two of them. And the other 10 have been shown here and there on occassion. The Magdelena character carries one of them, which is the Spear of Destiny. And we introduced a couple new ones at the end of Broken Trinity.

"We've kind of been scattering these things through the books, and finally, this mini-series event is going to identify all of them and bring all of them together," he said.  "Finn is trying to stop the artifacts from coming together, but his opposite number is a woman called Gloriana Silver, who discovered the ember stone. Her obsession is to try to bring these artifacts together. And we've sort of given the idea that if these artifacts come together, it's not a good thing. This series is specific as to what happens when these artifacts come together."

As readers might notice, there are 13 artifacts and 13 issues -- and that's not a coincidence. "It's our intention to concentrate on one artifact per issue, but that might not be an absolute rule as we get into it because obviously, we want to make sure we get the story across in those issues," he said.

Artifacts will be the third act in a larger story that Marz has told through his last two crossover events for Top Cow, although Marz pointed out that this one is much bigger and has more implications than the prior ones.

"The last few years, Top Cow and I have done smaller-scalle crossover events. We did the first one, which was Sara Pezzini, who was the Witchblade bearer, having a baby. And last year we did Broken Trinity, which introduced some new characters and new artifacts into the universe," he explained. "Those were six-issue events, with three issues of the main title and three tie-in issues. So we generally kept these crossover things fairly small and manageable, as opposed to a huge Marvel or DC crossover, where you're talking about 30 or 40 books and $150 bucks or something like that.

"So we're essentially doubling the scale of what we're doing," Marz said. "It'll pull in a lot of different aspects of the Top Cow universe and the scope of it will be larger than any of the crossover events we've done before."

This summer we see another Top Cow and Marvel Crossover, featuring teams: Cyberforce, Hunter-Killer from Top Cow and Thunderbolts and Mighty Avengers from Marvel.

In a display of how much importance Norman Osborn and the Thunderbolts have achieved in the Marvel Universe, the team is getting equal billing with the Avengers in Top Cow's latest inter-company crossover, entitled Fusion: Cyberforce/Hunter-Killer/ Avengers/Thunderbolts

The three-issue limited series begins in May and Top Cow has provided Newsarama with a first look at Mike Choi's cover to the debut issue.

Fusion: Cyberforce/Hunter-Killer/Avengers/Thunderbolts #1 (of 3)
(W) Dan Abnett & Andy Lanning (A) Tyler Kirkham (Cov) Mike Choi & Sonia Oback

The mother of all Top Cow/Marvel crossovers debuts in May! Top Cow's two covert tech teams collide with Marvel's Initiative enforcers, the Mighty Avengers and the Thunderbolts.

When a rapid and unregistered Ripclaw starts tearing through a small Northeast town, the Mighty Avengers move in to stop him. When the feral hero escapes, they're drawn into an inevitable conflict with Cyberforce. A crossover event too massive to be contained in a single issue brought to you by the writing team of Dan Abnett and Andy Lanning (Guardians of the Galaxy, Nova) and Top Cow favorite artist Tyler Kirkham (Ultimate Fantastic Four, Broken Trinity: Aftermath).

Since I was awesomed by the book, decided to post sort of preview here for all of you to look at.

This is a book set in future earth, where ghosts roam free. Science and police have adapted to them and officers called Detective exorcists deal with these supernaturals.