I believe I can say this is the story I've been waiting from Supergirl since her fall on Gotham in Superman/Batman 8.
It's not only about the story concept. Allgthout I never read a story where a superhero fight something he can't punch or trow at the jail, and I like it.
But the best part is that Supergirl is now more interesting. In this issue, and some before, she seams to have a more curious mind, definitely less dramatic, and with a lot more of initiative. Kara's more active, less "emo". I also find it very good that she's finally standing up for something. It's always better to a have a Supergirl with the mission to cure cancer, than one with the mission to kill Superman. (Who came up with that crap anyway?)
The bottom line is: this is a Supergirl who stands up for what she believes is right!