Character » Mysterio appears in 738 issues.
The son of Kraven the Hunter, he too is a skilled hunter and tracker. Unlike his father his enhanced abilities are natural and he can talk to animals.
13 year old daughter of Kraven the Hunter. Now walking in her father's footsteps, she continues the hunt for Spider-Man.
Dmitri Smerdyakov, AKA Chameleon, was first member of an inexperienced Spider-Man's rogue's gallery. The Chameleon is an elite spy and a master of disguise, using a variety of masks, technology, and other inventive techniques to flawless mimic the appearance and mannerisms of virtually anyone. Although he has been revealed to be the half-brother of Kraven The Hunter, the face behind his trade-mark white mask – worn even beneath his other masks – has never been seen.
Mysterio was a formidable foe to the amazing Spider-Man. So much so that his arts of illusion were carried on by others after the original Mysterio's death. Mysterio was Conundrum's master.
Diablo is a 9th century alchemist with aspirations of world dominance. He is able to produce any number of amazing potions that defy scientific analysis. Diablo does not seem to age. He is an enemy of the Fantastic Four.
Doctor Octopus was a member of the original Sinister Six, along with Mysterio.
Mysterio is part of the sinister six and formed an alliance with Electro during "Another Return of the Sinister Six" (ASM VOL. 2 ISSUE 12)
Francis Klum is Garrison's brother
fellow member of the 3rd version of the Sinister Six.
a Stuntman/Mercenary paid by Mysterio to kill Spider-Man. He was killed by the Symbiote in self-defense.
Roderick Kingsley became a worthy heir of the Goblin legacy, creating his own identity, of the Hobgoblin, rather than being just another Green Goblin clone.
Jason Philip Macendale, former agent of CIA, turned from the first Jack O'Lantern to the second major Hobgoblin and once the host of Demogoblin. He was rebuilt as a cyborg and remained Hobgoblin until the first Hobgoblin who was thought dead returned and killed him.
A demon who is obsessed with Spider-Man and helped Mysterio escape hell. He manipulated events so a number of Spider-Man's rogues would compete to kill Spider-Man to win their freedom from their inevitable torture in hell.
Teammates of the sinister six.
Fellow Sinister Six teammate during Sinister War
The second Mad Jack, Maguire Beck. Cousin and apprentice of Mysterio, former assistant to the first Mad Jack, Daniel Berkhart. Uses a combination of Goblin and Mysterio tech. Enemy of Spider-Man and Daredevil
Mysterio used Shiffman as a pawn in hopes of defeating Spider-Man.
Daughter of Mysterio (Quentin Beck).
Daniel Berkhart briefly posed as Mysterio as part of a larger plot, before taking up the Jack O'Lantern/Mad Jack identity. After Quentin Beck's suicide, Berkhart took up the mantle of Mysterio.
Nicholas Joseph Fury served in World War II as the leader of the Howling Commandos. He later became an agent, and eventually director, of S.H.I.E.L.D. Fury is one of the greatest strategic minds in the world, a born leader and a master of espionage. He currently serves as a replacement Watcher.
Deceased supervillain that fought Dead Girl in Hell.
The omnipotent ruler of the Regency who slaughtered all of its superheroes and harvested their powers years ago.
A career criminal, the man known as Rhino has incredible strength and durability. A long-time enemy of Spider-Man and the Incredible Hulk, Rhino isn't particularly malicious, and has tried on various occasions to leave behind his life of crime, but always seems to slide back into old habits.
Edward Nigma is a villain obsessed with riddles, puzzles, and brain teasers, who took the alias of the Riddler to commit crimes. Riddler frequently tries to outsmart Gotham's hero Batman, but is always defeated by the Dark Knight.
A scientific genius, Ruby Thursday remade herself into an living human gynoid with a shape-shifting head. She is a member of the villainous Headmen.
The Sandman was a member of the original Sinister Six, along with Mysterio.
Sasha was married to Kraven the Hunter.
MacDonald "Mac" Gargan was a failing private investigator that was turned into the Scorpion with financial help from J. Jonah Jameson. He became a host of the Venom symbiote and was part of Norman Osborn's Dark Avengers. After the US Government took the symbiote, he became The Scorpion once again.
Shocker is a supervillain originating from Marvel Comics. A self-taught engineer, Herman Schultz created a pair of gauntlets that produces shock waves incorporated into a suit that protects him from the impact of of the blasts. He is a recurring foe of the superhero Spider-Man.
Talos is a Skrull warrior that was unable to shapeshift and was therefore shamed by his Skrull-peers.
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