After his wife became terminally ill, Dr. Victor Fries devoted his life to saving her, and used cryogenics to buy some time to find a cure. After an accident, Fries must stay in a cryo-suit to live, becoming Mr. Freeze.
I know that he may a little old for the role now, but I'd choose Rutger Hauer. His confused and emotive role in Blade Runner as both a character to fear and sympathise is similar to that of how I think Mr. Freeze should be portrayed.
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