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Omega stands alone. Beyond the reach of galactic politics, the space station has provided a home for commerce unwelcome elsewhere for years - all its criminal gangs fearing its leader, the powerful asari biotic Aria T'Loak.
But there are those who do not respect Aria's rule - or anything else. Following Commander Shepard's successful expedition against the mysterious Collector menace, the prohuman organization Cerberus establishes bases beyond the Omega 4 relay to investigate the alien threat.
When Cerberus's experiments with Reaper technologies go wrong, a new threat emerges from the relay, ready to wreak destruction on an unsuspecting galaxy. The first stop on the path to utter destruction: Omega, which stands, as always, alone...