A beautiful young French actress, Laura Demille suffered extreme schizophrenic behaviour as the result of a car accident. The Brain and Monsiuer Mallah subjected Laura to a ray treatment that surpressed the positive side of her personality and greatly strengthened her latent evil tendencies. Renamed Madame Rouge, Demille joined the Brotherhood of Evil.

Later the Brain gave Rouge superhuman powers as well. The Brotherhood made their headquarters at a Parisian girls' school, L'Ecole des Filles, with Rouge acting as its headmistress. The Brotherhood clashed repeatedly with the Doom Patrol, and Madame Rouge and the Doom Patrol's Chief felt a growing attraction for one another. Eventually the Chief succeededin restoring Laura's original personality.

However, the Brotherhood used scientific means to force DeMille's evil side to surface again. She seemingly destroyed the Brain and Monsieur Mallah and then with new ally Captain Zahl, captured the Doom Patrol.

Zahl informed the Patrol that unless the four heroes allowed themselves to be killed, he would blow up a small New England fishing village. The four Doom Patrol members, including the Chief, courageously agreed to sacrifice themselves for the sake of the villagers. Over Madame Rouge's protests, Zahl blew up the land where the Doom Patrol were standing. It appeared that only Robotman survived.

Years later, Rouge and Zahl were opposed in their attempts to conquer the small country of Zandia by the New Teen Titans and they -along with Robotman, the Brain and Monsiuer Mallah - pursued the pair to Africa. There, Zahl was killed when a bullet he fired at Robotman ricocheted back at him, while Rouge was pursued by the vengeful Changeling (adopted son of Doom Patrol member Elasti-girl). Rouge was about to destroy herself and her foes when Changeling pushed her into some machinery. She thus suffered a fatal electrical shock that restored her true personality and she died repenting her crimes.