Luke Cage

Atlas (Erik Josten), formerly Power Man, Smuggler and Goliath is a member of the Thunderbolts. Erik was originally a mercenary convinced by the Enchantress to undergo ionic ray treatment that made him super strong. After adopting the Name Power Man and joining forces with the Enchantress for awhile, he decided to go on to become a supervillain on his own later joining teams such as the Lethal Legion and the Masters of Evil. He eventually met Luke Cage (also known as Power Man for a short time). The two fought and Cage won.

Big Brother was born into poverty and turned to a life of crime using his great intellect. After being jailed multiple times he came up with the ability to connect himself to computers. He was an enemy of Luke Cage's.

Giant dragon that can transform into a human.

She was a drug racketeering 400 lbs. woman who crossed paths with Luke Cage. Cage cmae toe-to-toe with Mariah, and shutdown her operation. She no doubt got her name from the alias of an ambulance, simbolizing the way she ran her operations.

Bulldozer & the rest of the Wrecking Crew battled members of the Defenders in one of their earliest appearances. Luke Cage aka Power Man was brawling with all the Wrecking Crew members.

Chaka has battled Luke Cage while he was Power Man for the group "Heroes for Hire". At the time Luke was partnered with Iron Fist.

A former SHIELD agent sent undercover. Constrictor soon became what he was trying to stop.

Luke Cage, wrongly convicted and unjustly imprisoned, was altered in a failed prison experiment that gave him bulletproof skin and super-human strength. His has a take-no-prisoners attitude now!

Willis Stryker, formerly friends with Luke Cage, framed Cage, who ended up in prison. Stryker was a knife specialist. He died when one of his own customized explosive knives detonated.

Victor Von Doom is the ruler of Latveria. Under his rule the country has flourished.

Edward Lavell took the mantle of the Eel from the deceased Leopold Stryke, and has upgraded his armor and technology to enhance his criminal lifestyle.

Ferocia is a alien werewolf from K'un Lun. She is an enemy of Iron Fist, Luke Cage and Misty Knight.

Luke Cage, wrongly convicted and unjustly imprisoned, was altered in a failed prison experiment that gave him bulletproof skin and super-human strength. His has a take-no-prisoners attitude now!

Perhaps Spider-Man's deadliest and most dangerous villain. There's no stopping what this madman will do to get what he wants.

Hardcore was a mercenary hired under Cruz Bushmaster, and an opponent of Luke Cage's. During Cage's brief stent in Chicago, he encountered Hardcore. Hardcore apperently died in a vehicle explosion. Hardcore is an excellent hand-to-hand combatent, and a master of traditional japanese weaponry, like manrikisas. The nails on one of his hands were medically augmented to give him the ability to slash through some of the toughest of metals.

James Lucas, Jr. is the brother of Luke Cage. He was given super powers with the sole purpose of fighting Cage. His alias was Coldfire.

Doctor Alejandro Cortez created a helmet that linked his mind with that of three other jungle cats. In doing so, they gained the ability of speech, and Cortez was gifted with cat like agility and skill.

Manslaughter is a supervillain in the Marvel Comics universe. He is a psychopathic killer who has fought the Defenders, and later briefly joined their team.

The New Avengers and the Autobots teamed up to fight against Dr. Doom and Megatron, to save a country from a useless war.

Mole man was the Fantastic 4's first enemy to fight when they first acquired their super powers. He dwells underground with an army of monsters.

Back in the 70's, Morgan was one of the highest crime bosses in New York, but he had the bad luck of becoming one of Luke Cage's enemies. He has since had little no appearances.