Liam lives in Derby, UK, with his wife Christina, and three children, Matylda, Lorcan and Jeff.

Liam made his debut in the 1980s for the famous science-fiction magazine 2000 AD after a year's apprenticeship with the legendary Don Lawrence, artist on the seminal Dutch comic "Storm". His works included many Judge Dredd stories – most notably stories featuring P.J.Maybe, whom he created with Wagner and Grant, and who became one of Dredd’s most popular villains. The origin of Finn, the ABC Warriors and a Tharg's Future Shock.

Liam's audience increased markedly when he moved to Marvel UK, for which he drew the best-selling Marvel UK title ever, the mini-series Death's Head II. Thereafter he began working mainly in the United States on books as diverse as the X-Men, the Hulk, Spider-Man, Venom, Man-Thing (for Marvel Comics), Superman, Batman, and The Possessed (for DC Comics and Wildstorm), Spawn: The Dark Ages (for Todd McFarlane) and Red Sonja for Dynamite comics.

Sharp has also worked on more mature themed books for Verotik, drawing GOTH, Jaguar God and Frank Frazetta's The Death Dealer. He briefly worked on a strip originated by Stan Winston, Realm of the Claw. He wrote and drew a strip for Heavy Metal magazine, entitled "A-crazy-A" featuring Playboy model Tiffany Taylor as the title character. Likewise he wrote and drew a critically well-received short story for Vampirella magazine called "Winter Rose".

In 2004 Sharp set up his own publishing company, MamTor™ Publishing, with wife Christina McCormack, to publish the art-book "Sharpenings: the Art of Liam Sharp".

After the early success with this, Sharp saw a hole in the comic book market for alternative independent comics, and together with designer Tom Muller and friend and comic art collector John Bamber set out to expand the company to start publishing more work. This saw the launch of the critically acclaimed and award-winning anthology "Event Horizon", and Matt Coyle's "ground-breaking" graphic novel "Worry Doll".

Liam is currently working on the controversial DC Vertigo title Testament with best-selling novelist and media commentator Douglas Rushkoff, and DC’s Countdown related mini-series “Lord Havok”.

Liam also worked on the movies "Small Soldiers", "Lost in Space", and the animated TV series "Batman Beyond."