Character » Lady Octopus appears in 102 issues.
Alistair Smythe is the son of Spencer Smythe: a mad scientist responsible for the creation of Spider-Slayers; robots designed to hunt and kill Spider-man. After his death Alistair carried on his work.
Wife of Override. She also wears cybernetic suit.
Syndicate recruit
Doc Ock's robotic sidekick/henchbot.
Delilah is a deadly assassin.
Doctor Octopus is a supervillain originating from Marvel Comics. A former nuclear physicist and atomic researcher, Otto Octavius' life changed forever when one of his experiments went horribly wrong involving his four mechanical appendages used to assist him in his experiments. From then on, Octavius soon after his initial encounter has become one of the most dangerous supervillains in the Marvel Universe.
Fellow Sinister Syndicate member
Goldbug is a minor villain, who was obsessed with gold. He has faced off against many heroes.
A mercenary known by the name of Override. He first met Ben Reilly, the Scarlet Spider, when he was hired to capture or kill him.
Kareem was invited to Beetle's bachelorette party
The one time ruler of Latveria during Secret War and a cyborg
The amoral industrialist Norman Osborn was transformed by an experimental serum into the maniacal Green Goblin, and has endured over the decades as Spider-Man's most dreaded archenemy. Osborn is known for being the killer of Gwen Stacy, the architect of the Clone Saga, and the one-time director of S.H.I.E.L.D.
A career criminal, the man known as Rhino has incredible strength and durability. A long-time enemy of Spider-Man and the Incredible Hulk, Rhino isn't particularly malicious, and has tried on various occasions to leave behind his life of crime, but always seems to slide back into old habits.
A genius in the fields of biology and genetic engineering as well as a close friend to Ben Reilly, the Scarlett Spider.
A former lover of Doctor Octopus and enemy of Spider-Man who uses virtual reality to become her alter-ego.
A professional killer hired by Carolyn Trainer during her stint as Doctor Octopus hired to kill Jason Tso as well as a number of her other enemies. Later faced off against the Scarlet Spider and later Spider-Man while he and a bunch of other villains tried to claim the bounty on a skeleton in as Spider-Man Costume
Son of Wilson and Vanessa Fisk. Took up the identity of The Rose to become a rival to his father, and later became Blood Rose to act as a vigilante who openly fought against his father.
A young new millennial Trapster.
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