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Girl Genius is the ongoing story of Agatha Heterodyne as she discovers her family history while "breaking though" as a Spark - an extremely creative person who can warp the laws of physics. Girl Genius is set on Earth, in the 1800s in an alternate universe.
After 13 issues, the comic moved to an online format at www.girlgeniusonline.com where it continues to be published on Mondays, Wednesdays and Fridays. Dead tree compilations are printed once a year or so. The authors are also working on a novelization of the comic.
A lot of effort has been put into maintaining the Wikipedia entry by fans.