I got to go with Cast Away. The difference being that thought that boy from Life of Pi did a very good job carrying the movie, Tom Hanks still does it better.
I also love the ending to Cast Away, when he's literally standing on a dusty crossroads and he stands facing each direction until turning and facing towards where he just came from with the slightest little grin. And just from that little bit of tremendous acting from Hanks, he's filled in all the blanks. We know where he's going and what he's looking for. Just amazing.