I can think of only 3 possible ones.
Superman, Batman, Spiderman.
Wonder Woman, despite being the most iconic female superhero, doesn't have lots of iconic villain.
Ironman, Hulk, Captain America and Thor, despite being popular all do not have a big cast of iconic villains.
X-men has a good amount of iconic villains but because they operate as a team, its kinda hard to define what is an iconic villain for X-men, since the line is pretty grey.
Wolverine would be a more well defined character to say that he has iconic villain, but he does not have that big a cast.
Green Lantern have a pretty big cast of iconic villains as well, but not sure if there are as many as Superman, Batman and Spiderman.
Flash have the rogues which has pretty popular villains but I'm not sure if they're iconic.
So if you have to choose 1 Superhero who do you think has the most iconic supervillains.