Returning reader, what are the major 616 comics to follow?

Hi, how are you doing? New poster here, I stopped following a few years ago during Dark Reign and I just returned to comic book reading. What are the major comics I need to follow in order to keep up with the major 616 storylines and continuity? Thank you in advance and I apologize if this is in the wrong section or if there's a thread somewhere already for this kind of thing