I think it's safe to say that they react a little bit faster than twice as fast as humans. Faora and Superman both dodged F-22 gunfire, and Faora snatched and evaded a close quarters speed blitz from Superman twice. Not to mention the super speed punches they were throwing...
As for the OP topic...MoS is one of the strongest recent cbm hero but there are others who could conceivably beat him like Ryan Reynolds GL (maybe), Silver Surfer (maybe), and some X-Men heroes(maybe).
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