COULD IT HAPPEN??

Quick question for Comic Vine fans. If Spider-Man and Flash was to fight would Spider-Man sense work and if so would itdt be any good use for that battle? Will Spider-Man beat the Flash?

Photon was able to knock him on his rear with energy projection (most likely light projection, could be various EM spectrum waves though):

So, I would bet his senses would warn him, but his body wouldn't be able to react in time. Especially if Flash was coming from an unseen location.

Additionally, I doubt he could do much to tag a Flash. Although Wally (iirc) has shown susceptibility to a bait & trap approach set up by Deathstroke, so it's possible that Spidey could prep webbing in a way to coerce a certain path from Flash, but again, that would take prep.

Without making the situation favour Spidey in some major ways, this is the most brutal of stompings.

Flash is too fast for his spider sense

Well, no. Even if spider sense grants him precog, it doesn't mean he will be able to keep up with him.

What'd happen is probably well demonstrated by sasuke vs orochimaru in naruto/ luffy vs snake sisters in one piece. Or every time spiderman gets hit :D (overloading the precog via speed)

Spiderman would get crushed.

If I was writing the story, yep.