Uzumaki: Naruto & Nagato. Senju: Hashirama. Uchiha: Madara, Itachi, Sasuke & Tobi/Obito. To death. No genjutsu. All at their most powerful. Itachi isn't sick, madara has his EMS and RG, Sasuke has his EMS. Non are edo version just their normal version. To death. Nagato is using the 6 path. Takes place in the hidden cloud village. All bloodlust and morals off. Provide reason.