The way I see it, Pyro probably has stronger control of fire, and Wraith has stronger psi powers, than Typhoid Mary has of either of those powers, but it will take at least some struggle for them before they beat her in those areas. Typhoid and Reaper have much more effective physical weapons/skills. Reaper's scythe can spin like a buzz saw and can shoot various energy blasts and gas.
So the question to me is, can Typhoid and Reaper close the 50' gap before Pyro and Wraith win the pyrokinetic and psionic struggle? Wraith may also throw a wrench in this by turning invisible (using TP illusions) or using his smoke pistol. He can also cause pain directly in a victim. I feel like it's close to 50/50.