Slade has different powers from Wade. While I don't know the details, I know that he was enhanced physically and mentally. He was superhumanly fast, strong and durable, and could process information at an accelerated rate. Batman could still contend with him despite his stats, but he was superhuman. And yeah, I think his powers came from a serum.. they "broke" Slade down to the core, and then rearranged him to make him the perfect soldier. He also gained a slight healing factor, but nothing near Deadpools. Think Captain America or Spider-Man.
Slade's Nth metal armor further increased his already superhuman stats.
Deadpool on the other hand got his healing factor from Wolverines DNA. He's not superhuman in any way apart from healing.
So yeah, in terms of powers they're different.
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