Something my little sister thought of.
As much of a Deadpool fan I am, I'd hand this to Thor.
But that's just my opinion.
Thor has his hammer.
Captain America has his sheild.
Deadpool has 3 grenades, 2 AK-47's, and 2 katana's.
Spider-Man has his web shooters.
They are fully aware of each others powers, and there is no prep time.
Who do you think would win?