Dr Strange has the ability to transform matter,his powers also include energy projection,thought projection,he can manipulate the universes ambient magical energy,travel in and out of dimensions,can use astral projection,mental possession, illusions casting, can cause mesmerism and lastly he has the ability to travel back in time. Considering he can do all that and the fullness of his power is still unknown I, I believe he can defeat Estacado, leaving the Darkness hostless and in check.
Before god created light the Darkness already existed, this is when the darkness got pissed off and took out its anger on humanity feasting on it until the Angelus came (Third most powerful) eventually the Darkness tricked/defeated the Angelus and screwed up the balance of order in the comics.
Um, God was the only one capable of beating The Darkness 100%
anything else barely beats the darkness.
The Angelus and Witchblade are of equals of the Darkness.
I'm not trying to create an argument here, but I honestly haven't seen the destructive capabilities that put either on the level of the Darkness tbh.
Before Jackie Estacado took over the mantle of the Darkness, the Angelus destroyed his kind for 300 years. It reigned supreme during her time. The present Angelus seems to show the most potential in balancing out the darkness as she has wielded the Witchblade and given free will unlike the other Angelus host.
The Witchblade can cancel out the Angelus and the Darkness from its host at a given point.