If that's the Spider-Man from the Amazing Spider-Man movie, I'm going to give it to the Xenomorph. 'Amazing' Spider-Man's spider sense was practically non existent. Xeno has too many weapons at it's disposal, most of them hidden, such as it's acid blood and second mouth. Only way to dodge these is to either know they're there, or have precognitive abilities, such as the Spider-Sense. Without either of these, Spidey gets face hugged.
I believe that Spider-Man can take, he has a significant advantage in agility and reflexes that would allow him to outmaneuver and keep distance from the Xenomorph while simultaneously utilizing the environment to incapacitate it.