Loki has summoned Superman to Marvel Earth for his own personal amusement, and has him under mind control leveling New York City.
Reed Richards is working a synthetic Kryptonite ray to take away Superman's powers. Superman discovers the plan and tries to stop him. Reed doesn't have time to finish the project and has to go with a half finished weapon. Reed shoots Superman stripping him of him of nearly all of his powers the moment before Superman completely incapacitates Richards.
Superman is left with his durability, heat vision, limited regeneration, but all other powers are gone. Superman has the strength and agility of a normal human with his physique. Wolverine enters the room, and is left 1 v 1 against Superman. Who wins the resulting fight?