In a straight up fight. Neither are armed, Deadpool doesn't have any guns or swords, Spider-Man doesn't have his web-shooters. It's an adamantium-walled dojo, enough for Peter to crawl on, but Deadpool could touch him if he jumped high. Who wins?
bs has not been done before spidey and deadpool have fought side-by-side but not against each other. but i do believe spidey would win( saying deadpool was caught without his weapons). the reason being spidey has super strength. deadpool would not "die" from losing his head. in the deadpool: suicide kings comic series he gets his head shot off by the punisher, he grows it back. also in suicide kings spidey and deadpool fight together.
" They fought against each other in Amazing Spider-man # 611. Deadpool was prepared to distract Spider-man, but there was no clear victor.
As for the fight, Spider-man takes it. "
They also faced off in Cable and Deadpool. Spider-Man had the clear edge, but Deadpool boasted how he wasn't using guns / explosives.
Regardless, Spider-Man stomps in this scenario.