It comes down to regular or noir. Mostly because Miguel has no spider-sense and therefor no warning if they decided to attack him from behind. Plus the weird light from Noir's goggles would screw up his eyes. After that, 616 takes due to experience and skill.
Ultimate without symbiote jumps around and then gets curbstomped.
I'd go with 2099. Miguel has no spider-sense, but he can compensate for it assuming he knows he's in a fight via his enhanced senses/reflexes. Additionally, O'Hara, unlike all the others, still has organic webshooters. He can also take more punishment than the other spidey's. Plus, he's got greater offensive abilities than the others(talons, his venomous bite)
The only thing that could be a problem for him is his fanboyishness at meeting the original actual spiderman.
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