WIthout prep, the IG, Cosmic Cube, and any other weapons Spawn pounds Thanos. The same would go if we went up against Ghost Rider. With the demon in control Thanos's only answer would be throwing a fit as he can't damage the Spirit of Vengeance, and continues to get owned.
"nice explanation but what if spawn just try to send him in a different dimension"
I was talking about the same setting for Thanos against the current Ghost Rider. Let me further add Divine Spawn would curbstomp Thanos with no problem.
Current Spawns Durability... not all that great