I know this matchup has been done already, but not with the latest version of Selene. She's at her full power, with her machine pistols, handguns, the sword she used to kill Victor and all equipment she used in the Underworld series. Blade is armed with a shotgun, handguns, his sword and all equipment we saw (although I don't know how effective most of it would be against Selene).
The fight takes place in the building where Blade fought Drake and his men, only abandoned. Bloodlust on. They both start behind cover.
Now, I know Blade has tons of experience killing vamps, but Selene is an elite Deathdealer and has almost no weaknesses after drinking Corvinus's blood. She's faster, stronger and at least equally skilled in h2h combat. Blade is probably superior with a sword though, and maybe a little better marksman. Now she's got several more years of experence fighting human soldiers during the Purge. I'd personally give this to her, but still with a lot of trouble. What do you think?