Well, i don't know many things about Apocalypse in full power, but if it was base apocalypse, Sasuke could win, people here love to forget that Naruto's charactets are in their most faster than most Marvel's characters, at least the Earth's characters.
But what could Apocalypse do against Sussano, amaterasu, Mangekyou, Shinra Tensei, Sasuke's teleport, and Sasuke can make clones to trick Apocalypse and other things too.
Apocalypse maybe have more brutal force, but Sasuke have more versality, he isn't an idiot, he will not just run in front Apocalypse and try stab him, if he have full prior knowledge, i could see Sasuke win this.
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